Project Dates: 5/1/2015 – 4/30/2020
The focus of this training program is improving the diagnosis, treatment, and prevention of AIDS-related tuberculosis, with an emphasis on multi-drug resistant tuberculosis (MDR-TB). Clinical and laboratory trainees conduct mentored research training projects in the following priority research areas:
- translational research on M. tuberculosis latency, persistence, and drug discovery;
- clinical trials of new drugs for the treatment of MDR-TB, including patients with HIV;
- maternal-child tuberculosis diagnosis, HIV/TB treatment, and prevention;
- community-based case detection of HIV/TB and MDR-TB molecular epidemiology;
- implementation science to scale-up new TB diagnostics and HIV/MDR-TB treatment.
The program also trains research staff including nurses (6), data managers (2), social workers (2), and pharmacists (2) to participate in the aforementioned research areas.
Haiti has the highest prevalence of HIV (2.2%) and tuberculosis (296/100,000) in the Western Hemisphere. There are an estimated 1,540 prevalent MDR-TB cases in Haiti, but only ~150 patients are currently treated, in large part due to the lack of skilled clinical and laboratory personnel. Therefore over 90% of MDR-TB patients are left untreated in the community. This public health risk is compounded by the fact that 1/3 of patients are also HIV-positive. The development and validation of new diagnostics and anti-tuberculous therapies, coupled with research training to build human resources capacity addresses this urgent need.