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Research

In addition to investigating topics in the ethical practice of medicine, the Medical Ethics Division works to elucidate and clarify the aspects of research studies that make them ethical. It also helps other researchers develop and conduct ethical studies. This service is run by Dr. Fins and Inma de Melo-Martin, Ph.D., M.S.

The Medical Ethics Division comprises the Ethics Core of the Medical College's Clinical and Translational Science Center (CTSC). Cathleen Acres, B.S.N., M.A. serves as a CTSC Research Subject Advocate, available to researchers and subjects to address issues involving subject rights and safety.

The Ethics Core provides a Research Ethics Consultation Service and supports a Research Subject Advocacy Program.

Divisional Research

The Division of Medical Ethics is engaged in research initiatives that explore a wide range of topics both in the practice of medicine and in medical research. These include, among others, patients' needs for autonomy and support, issues surrounding reproductive and genetic biotechnologies, end of life care, public health ethics and social justice, and the developing field of neuroethics.

Areas of Divisional Research:

Advance Directives

Dr. Fins led a team of researchers in studying the role of advanced directives and how patients and proxies understand their moral obligations to each other. A "proxy" is someone to whom patients grant legal power-of-attorney should they become incapable of making medical decisions for themselves. The results, which were published in the January 2005 issue of the Journal of Pain and Symptom Management, suggested that the pact between patients and their proxies is much deeper and more flexible than previously thought. "It appears that it's not so much a contract as it is a kind of covenant, based on mutual experience and trust. And our study found that, because of this trust, patients allow proxies discretionary moral judgment that allows them to go beyond cryptic instructions to either withhold or provide care," said Dr. Fins. Read the full press release here.

End-of-Life Care

A Palliative Ethic of Care

Dr. Fins is renowned internationally as a champion of the rights of patients to be treated as whole individuals and receive appropriate and ethical care, and especially of their right to make decisions concerning their treatment. During the past 15 years much of his work has focused on ethical issues related to the end of life and palliative care. His most recent book, "A Palliative Ethic of Care: Clinical Wisdom at Life's End", both explores why there are so many difficulties surrounding end-of-life care and presents a guide for clinicians to help patients and families set and achieve goals of care. He wrote it to help clinicians, residents, attorneys, and medical students understand the transition from curative care to palliative care and to guide them through the great complexities and difficulties involved. Much of the book grew out of Dr. Fins's experiences – as an internist who sometimes had to care for dying patients and as a physician leading ethics consultations.

The book puts death and dying into a broader social and philosophical context and examines why issues surrounding the right to die have been so difficult. It provides guidelines for goal setting and a strategy for effective palliative care, with the use of the Goals of Care Assessment tool (GCAT). The GCAT is a framework for exploring major issues encountered by patients with terminal illnesses, for identifying goals of care, and for achieving them in a way that best serves the patient and family. Read more here.

Dr. Fins wrote the original draft of a palliative care and training act that was recently signed into law by the New York State Legislature as part of Governor Spitzer's 2007 Budget Bill. Dr. Fins also analyzed and developed amendments to the act, which provides $2.1 million in grants to medical schools and $2.5 million in grants to residency training programs. The legislation additionally establishes a statewide Palliative Care Education and Training Council that will serve as a resource center for best practices at the end of life and in palliative care.

Ethics and the Biomedical Sciences

The Division of Medical Ethics is concerned with the many ethical issues surrounding advances in the fields such as genetics, reproduction, stem cell research and vaccinations. Among the issues that deserve exploration are: how to design ethical studies and recruit appropriate human subjects for testing new technologies, how much to regulate scientific research, and how to put into practice new medical technologies in a way that respects individual rights and social justice.

Much of the work of Inmaculada de Melo-Martín, Ph.D., M.S., focuses on these issues. Trained in philosophy and molecular biology, she is especially interested in research involving reproduction - including in vitro fertilization (IVF), genetic testing and gene transfer. She has published widely on these topics, both in journals and in several books. Her most recent book, "Taking Biology Seriously: What Biology Can and Cannot Tell Us About Moral and Public Policy Issues", offers an account of the often misguided discussions that take place about human biology and the consequences for ethics and public policy. It explores mistaken beliefs about the role of genes in human life held by both proponents and critics of behavioral genetics, reproductive cloning, and genetic testing, and calls attention to the social context in which both the science and our ethical precepts and public policies play a role.

To support her efforts, Dr. de Melo-Martín was recently awarded a grant from the National Science Foundation for her two-year project, "Biology and Ethics: Evaluating the Claim that Biotechnologies Pose a Threat to Human Dignity". This study will examine the ways in which the concept of human dignity is used in current debates about biotechnologies such as human genetic enhancement, the creation of human-nonhuman chimeras, and embryonic stem cell research. It will provide the first systematic assessment of what several influential scholars and recent national and international science policy documents mean when they say that these technologies threaten human dignity. Thus, the research can play a role in improving dialogue between the sciences and the humanities, and between the sciences and society.

Neuroethics

Over the past several years, Dr. Joseph Fins has pursued research focused on the neuroethical issues of disorders of consciousness. He is especially interested in the "minimally conscious" brain state, which is neurologically distinct from the vegetative state. Unlike vegetative patients, those in a minimally conscious state show intermittent intention, attention, and memory, and they have the potential to fully or partially recover.

Joseph Fins Nicholas Schiff

Drs. Joseph Fins and Nicholas Schiff

In collaboration with Nicholas D. Schiff, M.D., Associate Professor of Neurology and Neuroscience and Associate Professor of Public Health, Dr. Fins is working to understand the neuroscience of how people recover consciousness in order to elucidate clinical and ethical aspects of this impairment. In addition to discovering how best to treat minimally conscious patients, a major goal of their research is to have the knowledge to serve as advocates for brain injured patients, who have historically been neglected.

The past few years have seen exciting major developments:

  • In July 2006 senior author Dr. Schiff, lead author Dr. Henning Voss, Assistant Professor of Physics in Radiology, and Dr. Fins led breakthrough research on Terry Wallis, a 42-year-old patient who emerged from a minimally conscious state after 19 years. Published in the July 2006 issue of Journal of Clinical Investigation, the study found that Wallis may have regained speech and movement because his brain rewired itself by growing tiny new nerve connections to replace the old ones sheared apart in a car crash.
  • Dr. Fins received a Robert Wood Johnson Foundation Investigator Award in Health Policy Research for his proposal, "Minds Apart: Severe Brain Injury and Health Policy." The grant began in July 2007 and will continue for three years. It funds interdisciplinary research into how best to serve the needs of patients with severe brain injury and their families through better clinical services and the promotion of clinical research. The work is designed to improve clinician-family communication about brain injury, inform educational standards for professionals, and articulate a justification for research in patients who are unable to provide consent. Read the full press release here. Dr. Fins' efforts will result in a number of scholarly papers and a book to be published by Cambridge University Press.
  • Drs. Fins and Schiff were sought for expert commentary on the discovery of mental activity in a severely brain injured woman, in a study led by brain researcher Adrian Owen at the Medical Research Council Cognition and Brain Sciences Unit in Cambridge, England, and published in the journal Science. The Science article described functional M.R.I. tests that showed active language processing areas in the woman, who was thought to be in a vegetative state. Dr. Fins said that the imaging techniques used in the study could help identify which patients are most likely to emerge (from a vegetative state to minimal consciousness, and possibly to full consciousness) – once the tests are studied in larger numbers of unconscious people.
  • Dr. Fins, along with Nicholas Schiff, M.D., Associate Professor of Neurology and Neuroscience and Public Health, and Kathleen M. Foley, M.D.,Professor of Neurology and Neuroscience and Clinical Pharmacology at Weill Cornell Medical College, recently published a commentary in Neurology urging a nationwide epidemiological study of severely brain-injured patients. The paper reports on an Institutes of Medicine exploratory meeting on disorders of consciousness. The meeting committee was chaired by Dr. Foley, with Drs. Fins and Schiff serving as members. Read the full press release here.
  • Dr. Fins testified on July 18, 2007, before the U.S. House of Representatives Committee on Veteran's Affairs hearing on traumatic brain injury (TBI). Dr. Fins called attention to the compelling needs of minimally conscious patients, both among the military and civilian populations. Read his testimony, which includes specific recommendations for improving care, here.
  • Dr. Schiff was the lead author of a groundbreaking study on the success of deep brain stimulation (DBS) in improving the condition of a severely brain injured man who had been in a minimally conscious state for six years. Dr. Fins, a co-author of the article, formulated the ethical framework that guided the design and execution of the study, which represented a collaboration among researchers from the Cleveland Clinic, the JFK Johnson Rehabilitation Center for Head Injuries, and Weill Cornell Medical College. The report is titled "Behavioural Improvements with Thalamic Stimulation After Severe Traumatic Brain Injury" and appeared in the August 2, 2007, issue of Nature. Read the full press release here. The study's findings were covered extensively in the media.

Research Ethics Consultation Service

The Weill Cornell Research Ethics Consultation Service was formed to help ensure that the university's biomedical research involving human subjects met the highest ethical standards. The service's formation was based on the realization that promoting research integrity needs to go beyond regulation - it has to be integrated into the fabric of scientific research.

The service is composed of three faculty members of the Division of Medical Ethics: Joseph J. Fins, M.D., M.A.C.P., Inmaculada de Melo-Martín, Ph.D., M.S., and Cathleen A. Acres, R.N., M.A., who help researchers at every stage of a project to design and carry out ethical studies.

Research Ethics Consultation Service of the CTSC

Research Subject Advocacy

As part of the Ethics Core of Weill Cornell Medical College's Clinical and Translational Science Center (CTSC), the Division of Medical Ethics supports a Research Participant Advocacy Program.

Cathleen A. Acres, B.S.N., M.A., is a Research Subject Advocate in the CTSC, where she works with investigators and staff to ensure that studies are conducted safely and ethically, with protection of human subjects accorded the highest priority.

Research Participant Advocacy Program of the CTSC

Contact Information

Medical Ethics

Joseph J. Fins, M.D., Chief

Joan Walker, Administrative Director
435 E. 70th St., 4J
Tel: (212) 746-1126 
Fax: (212) 746-8738
jow9033@med.cornell.edu

Danielle Felman, Divisional Administrator
1300 York Avenue, Room M-522C
Tel: (212) 746-4834
Fax: (212) 746-8793
daf2034@med.cornell.edu

Kerrine Simone Carter, Administrative Assistant
435 E. 70th St., 4J
Tel: (212) 746-4246
Fax: (212) 746-8738
kec9045@med.cornell.edu

Division Events

Division News

Clinical Trials

Related Internal Links

PDF icon Medical Ethics Seminar Schedule

Related External Links

Department of Healthcare Policy and Research
CTSC Research Ethics Core