Led by Division Chief Fernando J. Martinez, clinical research within the division has been rapidly expanding. Our research programs range from leading a multi-center, NHLBI-sponsored consortium to identify undiagnosed COPD, to the early identification and defining outcomes in COPD. Similarly, we lead multicenter investigative studies in a broad range of interstitial lung diseases and participate in numerous federal and industry sponsored therapeutic trials. In the intensive care unit, Augustine M.K. Choi is the primary investigator on a phase three randomized trial of inhaled carbon monoxide in patient with acute respiratory distress syndrome. Our outcomes research programs include multiple ICU based studies utilizing our ICU REDCap database to study critically ill patients as well as use of the ARDSnet database to identify sub-phenotypes and endotypes of acute respiratory distress syndrome. Our division maintains a biobank of critical illness, a biobank of patients with concern for sepsis, a biobank of interstitial lung disease patients, as well as a database of endobronchial ultrasound procedures including patient outcomes.