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Endocrinology Research

Research

The division conducts promising state-of-the-art research to generate new knowledge and improve understanding with the ultimate goal of applying the latest scientific and medical advances for the prevention, detection, and treatment of patients with endocrine diseases.

Alonso Lab group photo
Alonso Lab

The focus of Dr. Alonso’s lab is to understand the molecular pathways that trigger pancreatic beta cell proliferation, to find approaches to make more beta cells to prevent or treat diabetes. Using knockout and transgenic mice, and human and mouse pancreatic tissue in culture systems, she is particularly interested in the intriguing relationship between the beta cell workload response and generation of new beta cells.

Goncalves Lab group photo
Goncalves Lab

The Goncalves’ lab uses animal models and human clinical trials to understand the effects of diet (e.g. ketogenic, fructose) and cancer on the metabolic pathways that control fat and muscle mass. Dr. Goncalves’ clinical practice is focused on metabolic diseases that are associated with high blood sugar (prediabetes, diabetes, fatty liver disease, high cholesterol) or the loss of skeletal muscle mass (low testosterone, cancer cachexia, etc).

Hollenberg Lab group photo
Hollenberg Lab

The focus of Dr. Anthony Hollenberg’s laboratory is the molecular action of thyroid hormones. Dr. Hollenberg was among the first to identify that thyrotropin-releasing hormone (TRH) neurons in the hypothalamus serve as integrators of metabolic input, setting thyroid hormone levels within the context of body weight. He was also among the first to identify the role of specific co-repressors in negative regulation by the thyroid, helping to establish the idea that hormone sensitivity is due to the quantity of co-repressors present. Dr. Hollenberg has had an independent research laboratory since 1993 and with continuous funding from the NIH since 1995. Recently, the Hollenberg Laboratory has begun a new program investigating the development of functioning thyroid follicular cells from embryonic stem cells.

Vella Lab group photo
Vella Lab

The Vella Lab’s long-term goal is to therapeutically target the mechanisms controlling the setpoints of the Hypothalamic-Pituitary-Thyroid (HPT) Axis to improve weight loss efforts. 90% of individuals who lose weight ultimately return to their previous weight within 5 years due in part to a suppressed basal metabolic rate (BMR). Thyroid hormone a major regulator of BMR. We use mouse models and chemogenetics to investigate the neuronal inputs that regulate the HPT axis, thyroid hormone levels and ultimately BMR.

Current grants

Clinical and Translational Science Center (CTSC) Weill Cornell Medical College’s $49 million NIH-funded Clinical and Translational Science Award (CTSA).
PI: Dr. Julianne Imperato-McGinley

NCI K08 CA230318. The Role of Hypoketonemia in the Cancer Anorexia-Cachexia Syndrome.
PI: Dr. Marcus Goncalves

NIDDK R01 DK105029. Thyroid Follicular Cell Development in Mice and Humans.
PI: Dr. Anthony Hollenberg

NIDDK R01 DK117940. Thyroid Hormone Signaling in Human Hepatocytes.
PI: Dr. Anthony Hollenberg

NIDDK R01 DK056123. Corepressor Regulation of Nuclear Receptor Action.
PI: Dr. Anthony Hollenberg

NIDDK, The Epidemiology of Diabetes Intervention and Complications Trial (EDIC), a continuation of the multicenter Diabetes Control and Complications Trial (DCCT) evaluating the effect of intensive glucose control on both microvascular and macrovascular complications of diabetes.
Site PI: Dr. Naina Sinha

The Louis and Rachel Rudin Foundation, Inc. Research on Reversing Pre-Diabetes by Utilizing a Change in Food Order.
PI: Alpana Shukla

NIDDK R01 DK113300. Role of GRP78 in beta cell adaptation in obesity and diabetes.
PI: Dr. Laura C. Alonso

NIDDK R01 DK114686. ATF6 and the Beta Cell.
PI: Dr. Laura C. Alonso

NIDDK R01 DK124906. Role of Polyamines and Hypusine in Nutrient-Induced Beta-Cell Growth and Replication.
PI: Dr. Laura C. Alonso

NIDDK R01 DK060581. Transcriptional and Translational Mechanisms Governing Beta Cell Function.
PI: Dr. Laura C. Alonso

NIDDK R01 DK117137. Regulation and Function of the Type 2 Diabetes-Associated C2CD4A/B Locus.
PI: Dr. Laura C. Alonso

ADA 1-18-IBS-233. T2D risk-SNPs at the CDKN2AB locus.
PI: Dr. Laura C. Alonso

WCMC Department of Medicine Fund for the Future Program.
PI: Dr. Megan Ritter

ATA The Role of Nuclear Corepressor 1 in Thyroid Hormone Signaling.
PI: Dr. Megan Ritter

United Health Group SS 202201-01. Weill Cornell Medicine United Health Group Clinical Scholars Program in Obesity Medicine.
PI: Dr. Louis Aronne