Department of Medicine

Research

Research

The division conducts promising state-of-the-art research to generate new knowledge and improve understanding with the ultimate goal of applying the latest scientific and medical advances for the prevention, detection, and treatment of patients with endocrine diseases.

Drs. Anthony Hollenberg, M.D., Marcus Goncalves, M.D., Ph.D., M.S.E., and Kristen Vella, Ph.D. began their research in the new Belfer Building in 2018. The focus of Dr. Anthony Hollenberg’s laboratory is the molecular action of thyroid hormones. Dr. Hollenberg was among the first to identify that thyrotropin-releasing hormone (TRH) neurons in the hypothalamus serve as integrators of metabolic input, setting thyroid hormone levels within the context of body weight. He was also among the first to identify the role of specific co-repressors in negative regulation by the thyroid, helping to establish the idea that hormone sensitivity is due to the quantity of co-repressors present. Dr. Hollenberg has had an independent research laboratory since 1993 and with continuous funding from the NIH since 1995. Recently, the Hollenberg Laboratory has begun a new program investigating the development of functioning thyroid follicular cells from embryonic stem cells.

In 2019, Dr. Laura Alonso, M.D. was recruited to the Division of Endocrinology, Diabetes, and Metabolism to serve as Division Chief and as Director of the Joan and Sanford I. Weill Center for Metabolic Health. Dr. Alonso is a leading investigator in pancreatic beta cell regeneration. The beta cells in the pancreas make insulin to help the body process sugar, but in type 1 diabetes, patients’ beta cells have been destroyed by the immune system, and in type 2 diabetes, patients have too few beta cells to meet the increased insulin needs of the body. Dr. Alonso’s research focuses on understanding how the pancreas in healthy people is able to produce enough beta cells to meet their need for insulin, with the goal of leveraging these discoveries to improve patient care. Even with the best therapies currently available, many patients with diabetes are not able to achieve adequate blood sugar control, and existing therapies (e.g., insulin injections) are expensive and do not address the root cause of the disease: shortage of beta cells.

Grants include:

Clinical and Translational Science Center (CTSC) Weill Cornell Medical College’s $49 million NIH-funded Clinical and Translational Science Award (CTSA).
PI: Dr. Julianne Imperato-McGinley 

NCI K08 CA230318. The Role of Hypoketonemia in the Cancer Anorexia-Cachexia Syndrome.
PI: Dr. Marcus Goncalves

Lung Cancer Research Foundation. Molecular Mechanisms of Cachexia in Non-Small Cell Lung Cancer.
PI: Dr. Marcus Goncalves

NIDDK R01 DK105029. Thyroid Follicular Cell Development in Mice and Humans.
PI: Dr. Anthony Hollenberg

NIDDK R01 DK117940. Thyroid Hormone Signaling in Human Hepatocytes.
PI: Dr. Anthony Hollenberg

NIDDK R01 DK056123. Corepressor Regulation of Nuclear Receptor Action.
PI: Dr. Anthony Hollenberg

NIDDK, The Epidemiology of Diabetes Intervention and Complications Trial (EDIC), a continuation of the multicenter Diabetes Control and Complications Trial (DCCT) evaluating the effect of intensive glucose control on both microvascular and macrovascular complications of diabetes.
Site PI: Dr. Naina Sinha

The Louis and Rachel Rudin Foundation, Inc. Research on Reversing Pre-Diabetes by Utilizing a Change in Food Order.
PI: Alpana Shukla

Contact Information

Endocrinology, Diabetes & Metabolism

Laura Alonso, M.D., Chief

Andrew Crawford, Administrator
1320 York Avenue, Rm HT-613
Tel: (212) 746-4113
ajc2007@med.cornell.edu

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Tel: (646) 962-5665
Fax: (646) 962-5687

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New York, NY 10065
Tel: (646) 962-2111
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Division of Endocrinology
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