Brown, Copertino, Corley, Craney, de Mulder Rougvie, Duarte, Ellsworth, Gulick, Iñiguez, Jones, Kapadia, Marin-Hernandez, Morales, Ndhlovu, Nixon, Petraitis, Powell, Saito, Salvatore, Satlin, Singh, Soave, Vorkas, Westblade, Walsh, Wilkin
Drs. Corley and Ndhlovu collaborated with colleagues from OHSU describe virological and immunological consequences of disruption of the CCR5 pathway in critical COVID-19 (published in International Journal of Infectious Diseases).
Drs. Corley, Evering and Ndhlovu, report on the role of caspases, pyroptosis, the inflammasome and the therapeutic potential of caspase inhibitors in SARS CoV2 infection and long COVID. (published in Allergy).
Mr. Copertino and Drs. de Mulder Rougvie, Duarte, Gulick, Nixon and Wilkin reported on antiretroviral drug activity and potential for pre-exposure prophylaxis against COVID-19 and HIV infection (pre-print published).
Drs. Craney, Salvatore, ad Westblade collaborated with colleagues from the Department of Physiology on the characterization of COVID-19 isolates in NYC and the development of a novel diagnostic method (published in Cell).
Drs. Craney, Satlin, and Westblade in collaboration with additional colleagues from the Department of Pathology compared two high-throughput reverse transcription-PCR systems for SARS-CoV-2 (published in the Journal of Clinical Microbiology).
Drs. Duarte, Iñiguez, Nixon, and Powell, Mr. Copertino and WCM medical student Jez Marston reported a data-driven approach to repurposing FDA-approved drugs for COVID-19 (pre-print published).
Drs. Ellsworth and Wilkin worked with colleagues in Department of Pathology and the blood bank to determine clinical factors in COVID-19 that were predictive of serologic responses in a convalescent plasma donor screening program (manuscript in preparation).
Dr. Jones co-authored a study that reported suboptimal biological sampling as a probable cause of false-negative COVID-19 diagnostic test results (published in the Journal of Infectious Diseases).
Dr. Jones co-authored a study that reported SARS-CoV-2-specific T-cells can be rapidly expanded for therapeutic use and target conserved regions of the membrane protein, (manuscript under revision in Blood).
Dr. Jones made his BSL-2+ space available as the primary site of processing of blood samples from SARS-CoV2-infected donors, for the WCMC Biobank effort (with Dr. Ross). He also supplied protocols to several other laboratories to establish their BSL-2+ procedures.
Drs. Marín-Hernández and Nixon and colleagues from the Division of Gastroenterology published epidemiological evidence for an association between higher influenza vaccine uptake in the elderly and lower COVID-19 deaths in Italy (published in the Journal of Medical Virology).
Dr. Ndhlovu collaborated with colleagues from the Division of Cardiology on the additive prognostic utility of adverse right ventricular remodeling in relation to conventional risk stratification among patients with COVID-19 (published in Journal of the American College of Cardiology).
Drs. Ndhlovu and Corley worked with colleagues from Mount Sinai and report on the overlap of intestinal inflammation and the pathogenesis of COVID-19 related disease on the SAR-CoV-2 receptors (published in Gastroenterology).
Dr. Nixon with medical students Jez Marston and Robert Wozniak reported on involvement of cisgender and transgender individuals in studies on the impact of hormonal therapy on COVID-19 (published in AIDS Patient Care and STDs).
Drs. Petraitis and Walsh used focal multivector ultraviolet technology (FMUV) for environmental control of SARS CoV-2 (technical report published).
Dr. Salvatore with colleagues Drs. Brown, Ellsworth, Kapadia, Morales, Saito, Singh, Soave, and Vorkas, working with a broad multi-disciplinary group recruited subjects to develop a biobank of specimens from hospitalized patients with acute COVID-19 as well as from outpatients who recovered (convalescent) to determine virologic and immunologic determinants of disease recovery or progression (published in Life Science Alliance).
Drs. Satlin and Westblade collaborated on a retrospective cohort study of blood culture utilization in COVID-19 and found bacteremia was very rare (published in the Journal of Clinical Microbiology).
Dr. Westblade has also collaborated on a number of SARS-CoV-2 diagnostic related studies (published in the Journal of Clinical Microbiology, Biosensors and Bioelectronics, and Clinica Chimica Acta).
Dr. Walsh in collaboration with Dr. Matt McCarthy received a grant from the Henry Schueler Foundation for translational research for new therapeutics with binary antiviral and anti-inflammatory properties in treatment of COVID-19.
- Dr. Ellsworth is working with colleagues in the Department of Pathology and Laboratory Medicine to define the specificity of SARS-CoV-2 serology by examining the test those that have recovered from other common coronavirus infections.
- Dr. Evering is the site principal investigator for an NIH ACTG study to investigate SARS-CoV-2 immune responses after COVID-19 therapy and subsequent vaccine.
- Dr. Jones was awarded an internal WCM grant as co-I (PI – Julie Blander from Gastroenterology) which aims to study antigen presentation mechanisms of SARS-CoV2.
- Dr. Jones generated a panel of SARS-CoV2-specific CD4+ T-cell clones from a convalescent donor, and has made these available to WCMC investigators, including collaborations with Drs. Robert Schwartz and Melody Zheng.
- Dr. Jones is serving as section editor for a special issue of Current Opinion in HIV & AIDS on intersections between the responses to HIV and COVID.
- Dr. Jones is serving as section editor for an issue of Frontiers in Microbiology on Immune Evasion Mechanisms by RNA Viruses, which will also emphasize intersections between HIV and COVID.
- Dr. Lee with Drs. Gramatica, Jones, and Wilkin are pursuing a Merck COVID-19 research grant, entitled “The LOVE Study: hyperacute and longitudinal dynamics of SARS-CoV-2 viral load and host immune responses in high-risk health care workers.”
- Dr. Salvatore is the site principal investigator of the Predictors of Severe Covid-19 Outcome (PRESCO) Study, a longitudinal multi-center, prospective, observational study collecting diverse biological measurements and clinical and epidemiological data to identify early signatures that predict progression to ARDS, mortality, and/or other comorbid conditions.
- Dr. Salvatore and others are conducing additional immune and biomarker development studies.
- Dr. Walsh and colleagues are submitting a grant proposal through the National Institute for Allergy and Infectious Diseases for the study of bacteriophages in treatment of bacterial pneumonia complicating experimental COVID-19.