Influenza Basic and Clinical Research Studies

Salvatore, Glesby, Gulick, Kaner

Dr. Mirella Salvatore is involved in clinical and translational studies of influenza in immunocompromised hosts. Specifically, she is the PI of an investigator-initiated study on combination therapy for influenza in the immunocompromised host and a phase 2 trial on a new long-acting antiviral for the prevention of influenza in high risk subjects. The CRU is a site for observational studies of influenza in outpatients conducted through the NIH-funded INSIGHT network and has participated in NIH-funded interventional trials of influenza in collaboration with Drs. Robert Kaner and David Berlin in the Division of Pulmonary & Critical Care Medicine.

Simonsen L, Higgs E, Taylor RJ, Wentworth D, Cozzi-Lepri A, Pett S, Dwyer DE, Davey R, Lynfield R, Losso M, Morales K, Glesby MJ, Weckx J, Carey D, Lane C, Lundgren J; INSIGHT FLU002 and FLU003 Study Groups. Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic. Clin Infect Dis. 2018 Jul 18;67(3):341-349.

Moroz E, Albrecht RA, Aden B, Beeder AB, Yuan J, García-Sastre A, Edlin BR, Salvatore M. Active opioid use does not attenuate the humoral responses to inactivated influenza vaccine. Vaccine. 2016 Mar 8;34(11):1363-9.

Fontana JM, Christos PJ, Michelini Z, Negri D, Cara A, Salvatore M. Mucosal immunization with integrase-defective lentiviral vectors protects against influenza virus challenge in mice. PLoS One. 2014;9(5):e97270. eCollection 2014. PubMed PMID: 24824623.

Zhou B, Deng YM, Barnes JR, Sessions OM, Chou TW, Wilson M, Stark TJ, Volk M, Spirason N, Halpin RA, Kamaraj US, Ding T, Stockwell TB, Salvatore M, Ghedin E, Barr IG, Wentworth DE. Multiplex Reverse Transcription-PCR for Simultaneous Surveillance of Influenza A and B Viruses. J Clin Microbiol. 2017 Dec;55(12):3492-3501.

Gallinaro A, Bona R, Michelini Z, Borghi M, Morante V, Grasso F, Calzoletti L, Canitano A, Salvatore M, Castrucci MR, Cara A, Negri D. Integrase Defective Lentiviral vector as a vaccine platform for delivering Influenza antigens. Front Immunol. 2018 Feb 5;9:171.

Ding T, Song T, Zhou B, Geber A, Ma Y, Zhang L, Volk M, Kapadia SN, Jenkins SG, Salvatore M, Ghedin E. Microbial Composition of the Human Nasopharynx Varies According to Influenza Virus Type and Vaccination Status. mBio. 2019 Jul 2;10(4):e01296-19.

Salvatore M*, Laplante JM, Soave R, Orfali N, Plate M, van Besien K, St George K. Baloxavir for the treatment of Influenza in allogeneic hematopoietic stem cell transplant recipients previously treated with oseltamivir. Transpl Infect Dis. 2020 Aug;22(4):e13336. Epub 2020 Jun 10. PubMed PMID: 32449254. *Corresponding author

Michelini Z, Minkoff JM, Yang J, Negri D, Cara A, Hanson BJ, Salvatore M. Integrase-Defective Lentiviral Vectors for Delivery of Monoclonal Antibodies against Influenza. Viruses. 2020 Dec 17;12(12). PubMed PMID: 33348840.

Rathnasinghe R, Salvatore M, Zheng H, Jangra S, Kehrer T, Mena I, Schotsaert M, Muster T, Palese P, García-Sastre A. Interferon mediated prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine lacking non-structural protein 1. 2021 Sci Rep 11, 22164. PMID 34401874

Wang C, Honce R, Salvatore M., D. Chow, D. Randazzo, Yang J, Twells NM, Mahal LK, Schultz-Cherry S and Ghedin E. Reduced inflammatory response and promoted multiciliated cell differentiation in mice protected by defective interfering influenza virus. doi: J Virol Accepted for publication