Influenza

Influenza Basic and Clinical Research Studies

Salvatore, Glesby, Gulick, Kaner

Dr. Salvatore is involved in clinical and translational studies of influenza in  immunocompromised hosts. She is also conducting basic research studies on the use of integrase-defective lentiviral vectors for immunization and antibody delivery against influenza. The CCTU is a site for observational studies of influenza in outpatients conducted through the NIH-funded INSIGHT network and has participated in NIH-funded interventional trials of influenza in collaboration with Robert Kaner and David Berlin in the Division of Pulmonary & Critical Care Medicine.

Simonsen L, Higgs E, Taylor RJ, Wentworth D, Cozzi-Lepri A, Pett S, Dwyer DE, Davey R, Lynfield R, Losso M, Morales K, Glesby MJ, Weckx J, Carey D, Lane C, Lundgren J; INSIGHT FLU002 and FLU003 Study Groups. Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic. Clin Infect Dis. 2018 Jul 18;67(3):341-349.

Rappo U, Schuetz AN, Jenkins SG, Calfee DP, Walsh TJ, Wells MT, Hollenberg JP, Glesby MJ. Impact of Early Detection of Respiratory Viruses by Multiplex PCR Assay on Clinical Outcomes in Adult Patients. J Clin Microbiol. 2016 Aug;54(8):2096-103.

Moroz E, Albrecht RA, Aden B, Beeder AB, Yuan J, García-Sastre A, Edlin BR, Salvatore M. Active opioid use does not attenuate the humoral responses to inactivated influenza vaccine. Vaccine. 2016 Mar 8;34(11):1363-9.

Zhou B, Deng YM, Barnes JR, Sessions OM, Chou TW, Wilson M, Stark TJ, Volk M, Spirason N, Halpin RA, Kamaraj US, Ding T, Stockwell TB, Salvatore M, Ghedin E, Barr IG, Wentworth DE. Multiplex Reverse Transcription-PCR for Simultaneous Surveillance of Influenza A and B Viruses. J Clin Microbiol. 2017 Dec;55(12):3492-3501.

Gallinaro A, Bona R, Michelini Z, Borghi M, Morante V, Grasso F, Calzoletti L, Canitano A, Salvatore M, Castrucci MR, Cara A, Negri D. Integrase Defective Lentiviral vector as a vaccine platform for delivering Influenza antigens. Front Immunol. 2018 Feb 5;9:171.

Ding T, Song T, Zhou B, Geber A, Ma Y, Zhang L, Volk M, Kapadia SN, Jenkins SG, Salvatore M, Ghedin E. Microbial Composition of the Human Nasopharynx Varies According to Influenza Virus Type and Vaccination Status. mBio. 2019 Jul 2;10(4):e01296-19.