The Division of Infectious Diseases collaborates closely with the Weill Cornell Center for Global Health (CGH), with nine faculty members shared between the two groups, including full-time faculty who live on-site or travel frequently to programs in Brazil, Haiti, India, and Tanzania.
Carvalho, Dupnik, Glesby, Johnson
The collaboration between Cornell University and the Federal University of Bahia started in 1964 and is the longest collaboration of its type in the world today. To date, over 20 Cornell faculty members and 120 students and fellows have participated in the program, and over 250 peer reviewed journal publications have emerged from the research. The program has been funded by the Commonwealth Fund and the Rockefeller Foundation, and since 1979, by the NIH. The current NIH funding supports our Tropical Medicine Research Center and a research training program in infectious diseases in Salvador, Brazil. A second program collaborates with the Federal University of Rio Grande do Norte (UFRN). Active areas of research include the pathogenesis, diagnosis, complications and management of HTLV-1, leprosy and leishmaniasis.
- Araújo SRF, Jamieson SE, Dupnik KM, Monteiro GR, Nobre ML, Dias MS, Trindade Neto PB, Queiroz MCP, Maia CE, Blackwell JM, Jeronimo SMB. Examining ERBB2 as a candidate gene for susceptibility to leprosy (Hansen's disease) in Brazil. Mem Inst Oswaldo Cruz 2014; 109:182-8.
- Dupnik KM, Bair TB, Maia AO, Amorim FM, Costa MR, Keesen TS, Valverde JG, Queiroz Mdo C, Medeiros LL, de Lucena NL, Wilson ME, Nobre ML, Johnson WD Jr, Jeronimo SM. Transcriptional changes that characterize the immune reactions of leprosy. J Infect Dis 2015;211:1658-76.
- Jirmanus L, Glesby MJ, Guimaraães LH, Lago E, Rosa ME, Machado PR, Carvalho EM. Epidemiological and clinical changes in American Tegumentary Leishmaniasis in an area of Leishmania (Viannia) Braziliensis transmission over a 20 year period. Am J Trop Med Hyg 2012; 86:426-33.
- Sundberg MA, Costa D, Orge G, Castro NM, Muniz A, Glesby MJ, Carvalho EM. Helminthic infection and the risk of neurologic disease progression in HTLV-1. J Clin Virol 2012; 53:251-55.
- Tanajura D, Castro N, Oliveira P, Neto A, Muniz A, Carvalho NB, Orge G, Santos S, Glesby MJ, Carvalho EM. Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. Clin Infect Dis 2015;61:49-56.
Fitzgerald, Dupnik, Johnson, Mathad, Ocheretina, Pape, Schackman
The Cornell program in Haiti began in 1980 with the establishment of a unit for the study and treatment of infantile diarrhea at the State University Hospital in Port-au-Prince. The Cornell team began its AIDS research in 1982 and was instrumental in the formation of Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO). Since 1983, Cornell and GHESKIO have had uninterrupted NIH support, resulting in over 130 publications. Cornell-GHESKIO conducts NIH-sponsored HIV and tuberculosis clinical trials. With support from the U.S. President's Emergency Program for AIDS Relief (PEPFAR), GHESKIO provides services to 500,000 persons annually. Current areas of research are HIV/AIDS, HPV and tuberculosis.
- Collins SE, Jean Juste MA, Koenig SP, Secours R, Ocheretina O, Bernard D, Riviere C, Calnan M, Dunning A, Hurtado Rúa SM, Johnson WD Jr, Pape JW, Fitzgerald DW, Severe P. CD4 deficit and tuberculosis risk persist with delayed antiretroviral therapy: 5-year data from CIPRA HT-001. Int J Tuberc Lung Dis 2015;19:50-7.
- Kimmel AD, Charles M, Deschamps MM, Severe P, Edwards AM, Johnson WD, Fitzgerald DW, Pape JW, Schackman BR. Lives saved by expanding HIV treatment availability in resource-limited settings: the example of Haiti. J Acquir Immune Defic Syndr 2013; 63:e40-48.
- Ocheretina O, Shen L, Escuyer VE, Mabou MM, Royal-Mardi G, Collins SE, Pape JW, Fitzgerald DW. Whole Genome Sequencing Investigation of a Tuberculosis Outbreak in Port-au-Prince, Haiti Caused by a Strain with a "Low-Level" rpoB Mutation L511P - Insights into a Mechanism of Resistance Escalation. PLoS One 2015;10:e0129207.
- Pape JW, Severe PD, Fitzgerald DW, Deschamps MM, Joseph P, Riviere C, Rouzier V, Johnson WD Jr. The Haiti Research-Based Model of International Public Health Collaboration: The GHESKIO Centers. J Acquir Immune Defic Syndr 2014; 65:S5-9.
- Shigyo K, Ocheretina O, Merveille YM, Johnson WD, Pape JW, Nathan CF, Fitzgerald DW. Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 2013; 57:2834-37.
A newer collaboration exists between Weill Cornell and Byramjee Jeejeebhoy Government Medical College (BJGMC) in Pune, India. BJGMC has received NIH funding for 20 years, producing over 100 publications in peer-reviewed journals. As an NIH international HIV clinical trials unit, research at BJGMC focuses on HIV and co-infections occurring in pregnant women and children. Since the collaboration began with Cornell in 2011, our fellows and students have conducted research on topics such as tuberculosis in pregnancy and dengue virus. BJGMC is currently conducting multiple trials as part of the NIH-sponsored International Maternal Pediatric Adolescent AIDS Trials Group (IMPAACT) and AIDS Clinical Trials Group (ACTG).
- Mathad JS, Gupta A. Tuberculosis in pregnant and postpartum women: epidemiology, management, and research gaps. Clin Infect Dis 2012; 55: 1532-49.
- Mathad JS, Bhosale R, Sangar V, Mave V, Gupte N, Kanade S, Nangude A, Chopade K, Suryavanshi N, Deshpande P, Kulkarni V, Glesby MJ, Fitzgerald D, Bharadwaj R, Sambarey P, Gupta A. Pregnancy differentially impacts performance of latent tuberculosis diagnostics in a high-burden setting. PLoS One 2014 Mar 21;9:e92308.
Downs, Fitzgerald, Johnson, Peck
In 2006, a formal affiliation was established between WCMC and the Weill Bugando School of Medicine (WBSM) / Bugando Medical Center (BMC) in Mwanza, Tanzania. BMC is a 900-bed tertiary care center serving a population of 13 million Tanzanians. WBSM admits approximately 150 medical students per class, per year. The goal of the Weill Cornell collaboration is to aid in the development of the WBSM/BMC infrastructure and training programs by the exchange of faculty, fellows, residents and students. Long-term goals include creation of a platform for self-sustaining research programs and clinical knowledge transfer. WCMC rotates approximately 40 senior teaching residents and fellows in medicine, pediatrics, surgery, and obstetrics and gynecology to Tanzania, and brings 10 Tanzanian physicians to New York for clinical and research training. Active areas of research are HIV/AIDS, schistosomiasis, sexually transmitted infections, tuberculosis, and non-communicable diseases such as hypertension.
- Chofle AC, Jaka H, Koy M, Smart LR, Kabangila R, Ewings FM, Mazigo HD, Johnson WD, Fitzgerald DW, Peck RN, Downs JA. Oesophageal varices, schistosomiasis, and mortality among patients admitted with haematemesis in Mwanza, Tanzania: a prospective cohort study. BMC Infect Dis 2014; 14:303.
- Downs JA, Kabangila R, Verweij JJ, Jaka H, Peck RN, Kalluvya SE, Changalucha JM, Johnson WD, van Lieshout L, Fitzgerald DW. Detectable urogenital schistosome DNA and cervical abnormalities six months after single-dose praziquantel in women with Schistosoma haematobium infection. Trop Med Int Health. 2013; 18(9):1090-06.
- Hokororo A, Kihunrwa A, Hoekstra P, Kalluvya SE, Changalucha J,Fitzgerald DW, Downs JA. High prevalence of sexually-transmitted infections in pregnant adolescent girls: a multi-community cross-sectional study. Sex Transm Infect 2015 (in press).
- Kayange N, Smart LR, Downs JA, Maskini M, Fitzgerald DW, Peck RN. The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania. PLoS Negl Trop Dis 2015 (in press).
- Peck RN, Luhanga A, Kalluvya S, Todd J, Fitzgerald DW, Downs JA. Predictors of tuberculosis in first six months after initiation of antiretroviral therapy: a case-control study. Int J Tuberc Lung Dis 2012; 16:1047-51.
- Peck RN, Shedafa R, Kalluvya S, Downs JA, Todd J, Suthanthiran M, Fitzgerald DW, Kataraihya JB. Hypertension, kidney disease, HIV and antiretroviral therapy among Tanzanian adults: a cross-sectional study. BMC Med 2014; 12:125 doi: 10.1186.