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Hospital Epidemiology, Infection Control, Antimicrobial Stewardship

Healthcare-Associated Infections

Calfee, Simon

The Infection Prevention & Control Department at NewYork-Presbyterian Hospital/Weill Cornell Medical Center has research activities ranging from traditional epidemiologic studies of infection risk factors and outcomes to intervention trials of infection control protocols and procedures. The primary goal of the research program is to improve patient safety by reducing the risk of healthcare-associated infections and antimicrobial resistance. Observational studies can be carried out utilizing infection control surveillance data, clinical microbiology data, and a robust hospital-based clinical database, which can be queried electronically. Previous and ongoing projects have studied patient-oriented and systems-based factors associated with transmission of multidrug-resistant organisms, device-related infections, procedure-related infections, and antimicrobial stewardship. In addition, the program has the potential for performing individual and cluster randomized trials of infection control interventions at Weill Cornell and in collaboration with Columbia University Medical Center. Fellows, residents, and students interested in epidemiologic research can choose from a wide variety of large or small projects depending on their needs.

For fellows interested in a career in hospital epidemiology and/or antimicrobial stewardship, there is opportunity to receive intensive training in this exciting field by participating in the Masters of Science in Clinical and Translational Investigation Program, or the Graduate Program in Clinical Epidemiology and Health Services and through direct participation in the Hospital Epidemiology Program.

Albert K, Ross B, Calfee DP, Simon MS. Overreporting healthcare-associated C. difficile: A comparison of NHSN LabID with clinical surveillance definitions in the era of molecular testing. Am J Infect Control. 2018 Sep;46(9):998-1002.

Martin EK, Salsgiver EL, Bernstein DA, Simon MS, Greendyke WG, Gramstad JM, Weeks R, Woodward T, Jia H, Saiman L, Furuya EY, Calfee DP. Sustained improvement in hospital cleaning associated with a novel education and culture change program for environmental services workers. Infect Control Hosp Epidemiol 2019 Sep;40(9):1024-1029.

Calfee DP, Davila S, Chopra V, Patel, Payal PK, Snyder A, Ratz D, Rolle AJ, Olmsted RN, Popovich KJ. Quantitative Results of a National Intervention to Prevent Hospital-Onset Methicillin-Resistant Staphylococcus aureus Bloodstream Infection: A Pre-Post Observational Study. Ann Intern Med. 2019 Oct 1;171(7_Suppl):S66-S72.

Calfee DP, O’Neil RP, Sylvester Q, Bosk JM, Sumer King Z, Langguth K, Lutterloh EC, Blog D. A regional initiative to improve cleaning of high-touch surfaces in long-term care facilities. Infect Control Hosp Epidemiol. 2020 Apr 14;1-4.

Wang TZ, White KN, Scarr JV, Simon MS, Calfee DP. Preparing your healthcare facility for the new fungus among us: An infection preventionist's guide to Candida auris. Am J Infect Control. 2020 Jul;48(7):825-827.

Hogle NJ, Balzer KM, Ross BG, Wuerz L, Greendyke WG, Furuya EY, Simon MS, Calfee DP. A comparison of the incidence of midline catheter-associated bloodstream infections to that of central line-associated bloodstream infections in five acute care hospitals. Am J Infect Control; 2019. Dec 5 S0196-6553(19)30959-9.

Antibiotic Stewardship

NewYork-Presbyterian Hospital has a long-standing antimicrobial stewardship program (ASP). The ASP is a joint effort between the Divisions of Infectious Diseases, the Departments of Pharmacy and the Departments of Microbiology across NYP/Weill Cornell, NYP/Columbia and other NYPH campuses. In 2018, the IDSA recognized NYPH’s ASP as a Center of Excellence. The program aims to

  1. optimize antimicrobial use through promoting judicious and effective antimicrobial prescribing, and
  2. improve patient outcomes by reducing antimicrobial resistance, the likelihood of adverse drug reactions, the risk of Clostridium difficile infection (CDI), and healthcare costs.

The NYPH ASP utilizes VigiLanz, a dedicated antimicrobial stewardship software platform, to identify ASP opportunities. There is ample opportunity for fellows to participate in ASP-related activities and research at Cornell and collaborate across all NYPH campuses. Examples of recent ASP-related research include:

Tang SJ, Gupta R, Lee JI, Majid AM, Patel P, Efird L, Loo A, Mazur S, Calfee DP, Archambault A, Jannat-Khah D, Dargar SK, Simon MS. Impact of Hospitalist-Led Interdisciplinary Antimicrobial Stewardship Interventions at an Academic Medical Center. Jt Comm J Qual Patient Saf. 2019 Mar;45(3):207-216.

Kapadia S, Abramson E, Carter E, Loo A, Kaushal R, Calfee DP, Simon MS. The Expanding Role of Antimicrobial Stewardship Programs in US Hospitals: Lessons Learned from a Multisite Qualitative Study. Jt Comm J Qual Patient Saf. 2018 Feb;44(2):68-74.

Salsgiver E, Bernstein D, Simon MS, Eiras D, Greendyke W, Kubin CJ, Mehta M, Nelson B, Loo A, Ramos LG, Saiman L, Furuya EY, Calfee DP. Knowledge, attitudes, and practices regarding antimicrobial stewardship among antimicrobial prescribers at five acute care hospitals. Infect Control Hosp Epidemiol. 2018 Mar;39(3):316-322.

Greendyke WG, Carter EJ, Salsgiver E, Bernstein D, Simon MS, Saiman L, Calfee DP, Furuya EY. Exploring the Role of the Bedside Nurse in Antimicrobial Stewardship: Survey Results From Five Acute-Care Hospitals. Infect Control Hosp Epidemiol. 2018 Mar;39(3):360-362.

Simon MS, Sfeir MM, Calfee DP, Satlin MJ. Cost-effectiveness of ceftazidime-avibactam for treatment of carbapenem-resistant Enterobacteriaceae bacteremia and pneumonia. Antimicrob Agents Chemother. 2019 Sep 23;63(12).