David Montrose, Ph.D., an Instructor of Pharmacology in the Division of Gastroenterology and Hepatology, has been awarded a 2-year grant from the Prevent Cancer Foundation. Dr. Montrose’s project – Modulating the Microbiota and Metabolome for GI Cancer Prevention – was selected for funding after a rigorous review by the Foundation.
The project, set to begin in January 2018, is focused on determining whether the chemopreventive effects of the COX-2 inhibitor celecoxib, are exerted in part, through altering the intestinal microbiota and gut luminal metabolites. The connection between these factors and intestinal stem cell behavior will also be explored. These studies are based on work that was published in Cancer Prevention Research in 2016, for which Dr. Montrose served as lead author. More broadly, his research is focused on understanding the interplay of host and luminal metabolism in the gastrointestinal tract in an attempt to elucidate how these factors impact the pathogenesis of neoplasia and inflammation.