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Dr. Guo Publishes Pivotal Paper in Science on Genome Editing of Gut Bacteria

Dr. Chun-Jun Guo

Dr. Chun-Jun Guo, Assistant Professor of Immunology in Medicine, Division of Gastroenterology and Hepatology, is lead author on a new study published in Science that has targeted a bacterial species - Clostridium sporogenes – commonly found in the human intestines. To carry out the research, Dr. Guo, and colleagues developed a new tool (CRISPR-Cas-based genome editing system). The study has yielded breakthroughs to help illuminate a growing body of evidence that gut microbial metabolites play a critical role in mucosal immunity and inflammation.

Dr. Guo’s colleagues on the study included researchers at Stanford University and the University of California, San Francisco. Funding for this project included a Director’s New Innovator Award from the NIH assigned to Dr. Guo.

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