In an effort to better understand the epidemiology of community associated respiratory viruses, Dr. Small is characterizing the epidemiology and risk factors for development of human rhinovirus (HRV) respiratory tract infections in HSCT recipients. Dr. Small is conducting clinical trials with novel antiviral agents against viral respiratory tract infections. These studies, including respiratory syncytial virus (RSV), influenza, parainfluenza, CMV, and COVID-19 infections will provide our patients with new agents that may improve outcome from these serious infections in our immunocompromised population. The epidemiology of respiratory viral infections in these patients continues to evolve and will be the subject of further study. Immunization is an important adjunct to the management of viral infections in immunocompromised patients.
Salvatore M, Satlin MJ, Jacobs SE, Jenkins SG, Schuetz AN, Moss RB, Van Besien K, Shore T, Soave R. DAS181 for Treatment of Parainfluenza Virus Infections in Hematopoietic Stem Cell Transplant Recipients at a Single Center. Biol Blood Marrow Transplant. 2016 May;22(5):965-70.
Linder K, Kovacs C, Mullane K, Wolfe C, Clark N, Small C, et al. Letermovir Treatment for Established Cytomegalovirus Infection in Transplant Recipients. [abstract]. Am J Transplant 20 (suppl 3, 2020).
Kodiyanplakkal RP, Brown M, Guarneri D, Soave R, Drelick A, Shore T, Gergis U, Mayer S, Phillips A, Hsu J, Walsh T, Small C, van Besien K. Efficacy of Letermovir Prophylaxis in Cytomegalovirus Seropositive Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving in-Vitro-T-Cell Depletion. Presented at EBMT, Frankfurt Germany, March 2019.
Chemaly RF, Dadwal SS, Bergeron A, Ljungman P, Kim YJ, Cheng GS, Pipavath SN, Limaye AP, Blanchard E, Winston DJ, Stiff PJ, Zuckerman T, Lachance S, Rahav G, Small CB, Mullane KM, Patron RL, Lee DG, Hirsch HH, Waghmare A, McKevitt M, Jordan R, Guo Y, German P, Porter DP, Gossage DL, Watkins TR, Marty FM, Chien JW, Boeckh M. A phase 2, randomized, double-blind, placebo-controlled trial of presatovir for the treatment of respiratory syncytial virus upper respiratory tract infection in hematopoietic-cell transplant recipients. Clin Infect Dis. 2019 Dec 3:ciz1166.
Marty FM, Chemaly RF, Mullane KM, Lee DG, Hirsch HH, Small CB, Bergeron A, Shoham S, Ljungman P, Waghmare A, Blanchard E, Kim YJ, McKevitt M, Porter DP, Jordan R, Guo Y, German P, Boeckh M, Watkins TR, Chien JW, Dadwal SS. A Phase 2b, Randomized, Double-blind, Placebo-Controlled Multicenter Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of Presatovir in Hematopoietic Cell Transplant Recipients with Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract. Clin Infect Dis. 2019 Dec 3:ciz1167.