In a collaborative study, investigators have implemented advanced technology and analytics to map, at single-cell resolution, the cellular landscape of diseased lung tissue in severe COVID-19 and other infectious lung diseases.
Investigators found that patients with Crohn’s disease have an overabundance of an inflammation-producing gut bacteria. A metabolite produced by this bacteria interacts with the immune system cells in the lining of the intestine.
Dr. Leandro Cerchietti and colleagues have published a paper in Cancer Discovery that has revealed a critical connection between lymphoma tumors and their microenvironments, which consist of different ecosystems of cells and treatment responsiveness.
Dr. Ari Melnick and team have published a breakthrough finding in Nature Immunology that has identified Smc3 as a critical gene in the development of the body’s immune response (B cells).
Results from an international Phase 3 clinical trial have led to the U.S. Food and Drug Administration’s approval of oral azacytidine (Onureg) as a maintenance therapy for AML, which is now being used as part of standard patient care.
The researchers analyzed data from the REGARDS Study, which tracked cardiovascular-related outcomes in over 20,000 people for a decade, to identify adverse social determinants of health that can lead to a higher likelihood of a fatal heart attack.
Dr. Ari Melnick and colleagues have published breakthrough findings that show certain histone H1 mutations are drivers of lymphoma.
The award provides early-career scientists with $500,000 over five years to investigate the interplay between humans and pathogens, and how such encounters can lead to disease.
The award, which will support Dr. Rafii’s project to accelerate regenerative medicine technology, provides $1 million per year (including direct and indirect costs) for seven years.
Published in the Journal of the American College of Cardiology, Drs. Jonathan Weinsaft and Jiwon Kim have shown that an echocardiogram is a useful tool in evaluating COVID-19 patients who have damage to the heart’s right ventricle.
