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Dr. Lee and Colleagues Publish Breakthrough Study on Cell-free DNA Monitoring of UTIs

Dr. John R. Lee

Co-lead authors Dr. John R. Lee, Assistant Professor of Medicine at Weill Cornell Medical College, and Dr. Iwijn De Vlaminck, Assistant Professor of Biomedical Engineering from Cornell Engineering at Cornell University, Ithaca, NY have published a breakthrough study in Nature Communications that has demonstrated a new method for monitoring urinary tract infections (UTIs) that surpasses traditional methods. Entitled, “Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract,” the study, which utilized urine samples and cell-free DNA sequencing, yielded critical information on both the dynamics of infections and the patients’ particular biological responses. The cell-free technique is capable of diagnosing rare infections and it is expected that it will aid in early diagnosis and treatment of kidney transplantation.

This collaborative study included co-authors Dr. Manikkam Suthanthiran, Stanton Griffis Distinguished Professor of Medicine, Division of Nephrology and Hypertension; Dr. Darshana Dadhania, Associate Professor of Medicine, Division of Nephrology and Hypertension; and Dr. Lars Westblade, an Assistant Professor of Pathology at Weill Cornell Medicine.

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