IPF develops when the lungs become damaged or scarred, making it difficult to breathe. Researchers have long been searching for a better mechanistic understanding of IPF that could lead to better treatment.
Four faculty in the WDOM have received the ASCI Council Young Physician-Scientist Award. This prestigious award recognizes physician-scientists who are early in their first faculty appointment and have made notable achievements in their research.
In a collaborative study, investigators have implemented advanced technology and analytics to map, at single-cell resolution, the cellular landscape of diseased lung tissue in severe COVID-19 and other infectious lung diseases.
Investigators found that patients with Crohn’s disease have an overabundance of an inflammation-producing gut bacteria. A metabolite produced by this bacteria interacts with the immune system cells in the lining of the intestine.
Dr. Leandro Cerchietti and colleagues have published a paper in Cancer Discovery that has revealed a critical connection between lymphoma tumors and their microenvironments, which consist of different ecosystems of cells and treatment responsiveness.
Dr. Ari Melnick and team have published a breakthrough finding in Nature Immunology that has identified Smc3 as a critical gene in the development of the body’s immune response (B cells).
Results from an international Phase 3 clinical trial have led to the U.S. Food and Drug Administration’s approval of oral azacytidine (Onureg) as a maintenance therapy for AML, which is now being used as part of standard patient care.
The researchers analyzed data from the REGARDS Study, which tracked cardiovascular-related outcomes in over 20,000 people for a decade, to identify adverse social determinants of health that can lead to a higher likelihood of a fatal heart attack.
Dr. Ari Melnick and colleagues have published breakthrough findings that show certain histone H1 mutations are drivers of lymphoma.
The award provides early-career scientists with $500,000 over five years to investigate the interplay between humans and pathogens, and how such encounters can lead to disease.